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Results for "

CBR1 Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (4) Autophagy (1) CCR (1) Endogenous Metabolite (2) NF-κB (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155587

Hydroxy-PP	Others	Cancer
Hydroxy-PP is a potent CBR1 inhibitor with an IC₅₀ value of 0.78 μM. Hydroxy-PP also potently inhibits the cytoplasmic tyrosine kinase Fyn with an IC₅₀ value of 5 nM .

HY-121710

MonoHER 7-Monohydroxyethylrutoside	Others	Cardiovascular Disease
MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner .

HY-157448

CBR1-IN-6

Apoptosis Cancer

CBR1-IN-6 (compound 1a) is a CBR1 inhibitor with chemosensitizing and cardioprotective activities .
HY-157450

YF-Mo1

Apoptosis Cancer

YF-Mo1 (compound 9) is a CBR1 inhibitor with an IC₅₀ value of 1.1 μM .
HY-157451

CBR1-IN-7

Others Cancer

CBR1-IN-7 (Compound JV-2) is a human CBR1 inhibitor (IC₅₀=8 μM). CBR1-IN-7 can be used in cancer research .
HY-157447

CBR1-IN-4

Others Cancer

CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC₅₀=0.09 μM). CBR1-IN-4 can be used in cancer research .
HY-157449

CBR1-IN-5

Others Cancer

CBR1-IN-5 (compound 13o) is a potent inhibitor of CBR1 with an IC₅₀ of 0.1 μM .
HY-157445

CBR1-IN-3

Others Metabolic Disease

CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC₅₀ value of 0.034 μM .

CBR1-IN-6	Apoptosis	Cancer
CBR1-IN-6 (compound 1a) is a *CBR1* inhibitor with chemosensitizing and cardioprotective activities .

YF-Mo1	Apoptosis	Cancer
YF-Mo1 (compound 9) is a *CBR1* inhibitor with an IC₅₀ value of 1.1 μM .

CBR1-IN-7	Others	Cancer
CBR1-IN-7 (Compound JV-2) is a human *CBR1* inhibitor (IC₅₀=8 μM). CBR1-IN-7 can be used in cancer research .

CBR1-IN-4	Others	Cancer
CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC₅₀=0.09 μM). CBR1-IN-4 can be used in cancer research .

CBR1-IN-5	Others	Cancer
CBR1-IN-5 (compound 13o) is a potent inhibitor of *CBR1* with an IC₅₀ of 0.1 μM .

CBR1-IN-3	Others	Metabolic Disease
CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC₅₀ value of 0.034 μM .

HY-13930

Miquelianin 3 Publications Verification Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Endogenous Metabolite	Cancer
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a *CBR1* inhibitor.

HY-157452

(8S)-Methyl zearalenone

Others Cancer

(8S)-Methyl zearalenone (ZEA analogue 5) is a selective CBR1 (carbonyl reductase 1) inhibitor, with an IC₅₀ of 0.21 μM .

(8S)-Methyl zearalenone	Others	Cancer
(8S)-Methyl zearalenone (ZEA analogue 5) is a selective CBR1 (carbonyl reductase 1) inhibitor, with an IC₅₀ of 0.21 μM .

HY-156694

Hydroxy-PP-Me	Apoptosis	Cancer
Hydroxy-PP-Me is a potent and specific *CBR1* inhibitor with an IC₅₀ of 759 nM. Hydroxy-PP-Me inhibits serum-withdrawal-induced apoptosis. Hydroxy-PP-Me increases As₂O₃-induced apoptotic cell death compared with As₂O₃ alone .

HY-N0148

Rutin Maximum Cited Publications 7 Publications Verification Rutoside; Quercetin 3-O-rutinoside	Amyloid-β Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and *CBR1* inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

Miquelianin 3 Publications Verification Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Flavonols Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Flavonoids other families Microorganisms Phenols Polyphenols Disease Research Fields Cancer	Endogenous Metabolite
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a *CBR1* inhibitor.

Rutin Maximum Cited Publications 7 Publications Verification Rutoside; Quercetin 3-O-rutinoside	Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Sunscreen Leguminosae Phenols Polyphenols Cosmetic Research Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

7,4'-Dihydroxyflavone 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Endocrinology	CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and *CBR1* inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

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CBR1 Inhibitor

Inhibitors & Agonists

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Natural
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